Low Dose Naltrexone

LDN is short for Low Dose Naltrexone. Naltrexone is a drug that was approved by the FDA in 1985 to treat opiate addiction and overdose. Typically, a 50 mg dose is utilized in these situations. Alternatively, a low dose, between 1mg and 4.5 mg has been utilized with success in certain conditions including autoimmune disease, cancer, chronic viral infections, fibromyalgia and many more. The combination of clinical and scientific research, physician and patient testimonials, and the safety profile of LDN make it an increasingly powerful option for those that suffer from these and other conditions. Biochemically, the low-dose and the standard high-dose naltrexone have different and paradoxic effects. A low dose of Naltrexone given typically at night before bed provides a short and transient blockade of opiate receptors throughout the body. This has shown to produce a reflexive increase in opioid growth factor(OGF) and an up-regulation of its receptors.  Opioid growth factor is an immune-system modulator that apparently turns off autoimmunity and regulates cancer growth in certain types of cancer. Here is a list of medical conditions of which LDN could help:

Autoimmune diseases:


  • multiple sclerosis
  • systemic lupus erythematosus (SLE/LED)
  • rheumatoid arthritis
  • ankylosing spondylitis
  • pemphigoid
  • sarcoidosis
  • scleroderma
  • Crohn's disease
  • ulcerative colitis aka colitis ulcerosa
  • Celiac disease
  • psoriasis
  • Wegener's granulomatosis
  • transverse myelitis
  • Hashimoto's thyroiditis, Graves' disease and other autoimmune forms of hypothyroidism and hyperthyroidism


Other illnesses:


  • hepatitis C
  • amyotrophic lateral sclerosis (ALS)/primary lateral sclerosis (PLS)
  • autism
  • Alzheimer's disease
  • Parkinson's disease
  • Behcet's disease
  • chronic obstructive pulmonary disease (COPD, emphysema)
  • endometriosis
  • fibromyalgia
  • chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)
  • irritable bowel syndrome (IBS)
  • chronic Lyme disease/post Lyme syndrome
  • polycystic ovary syndrome (PCOS)


Provided below are links to several websites that have more information about clinical research, patient testimonials, and other resources.




The LDN program here at The Lamkin Clinic begins with an initital consultation with baseline labs. Dr. Lamkin will spend around an hour discussing your unique situation, medical history, and performing an exam. Dr. Lamkin will discuss LDN therapy and make other recommendations based on your unique situation. These recommendations optionally may include other specialty lab testing, in-office diagnostics including bone desity testing or body composition analysis, nutrition consultation and guidance, in-office fitness testing including VO2 and resting metabolic rate, or even concomitant immunotherapy(LDA).

Dr. Lamkin will have either a phone or in-office follow-up monthly for three months then semi-annually in order to tailor your therapy. In addition, baseline labs will be repeated quarterly for the first year and then semi-annually therafter.

Please call us at (405) 285-4762 and speak with Deb for more information or to schedule an appointment.


Lamkin Clinic